The Hotel Twentyone is situated in the Prati district near Piazza del Popolo and the most loved touristic highlights. To reach the hotel by train from the railways station Termini you have to take the line A of the subway, direction Battistini, and get off at the stop Lepanto. The hotel is 400 meters far from the stop.
If you arrive at the Rome Fiumicino Airport you can reach the hotel by the train "Il Leonardo Express", with departures every 30 minutes to the railways station Termini.
If you arrive from the Rome Ciampino Airport the hotel is just few bus Stopps from Anagnina, deadline of the subway line A that you will take until the stop Lepanto.